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[Primary hyperparathyroidism and peptic ulcer].

P Gasparoni1, A Caroli, G Sardeo

  • 1Divisione Medica I, Ospedale Civile, Montebelluna.

Minerva Medica
|December 1, 1989
PubMed
Summary

Primary hyperparathyroidism is linked to a high prevalence of peptic ulcer disease, with over 22% of patients affected. This association, including Zollinger-Ellison syndrome, warrants further investigation into its underlying mechanisms.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Internal Medicine

Background:

  • Primary hyperparathyroidism is a condition involving overactive parathyroid glands.
  • Peptic ulcer disease is a common gastrointestinal disorder.
  • The relationship between these two conditions requires further clarification.

Purpose of the Study:

  • To determine the prevalence of peptic ulcer disease in patients with primary hyperparathyroidism.
  • To investigate the clinical presentation and potential associations of peptic ulcers in this patient group.

Main Methods:

  • Retrospective analysis of 35 patients with primary hyperparathyroidism observed between 1977 and 1987.
  • Review of patient records to identify peptic ulcer disease and Zollinger-Ellison syndrome.

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  • Analysis of serum levels of calcium, gastrin, and parathormone.

    • Main Results:

    • Peptic ulcer disease was found in 22.8% of patients (8/35), with 7 duodenal and 1 gastric ulcer.
    • In 14% of cases (5/35), peptic ulcer was the initial clinical sign of primary hyperparathyroidism.
    • Zollinger-Ellison syndrome was diagnosed in 8.5% of patients (3/35), representing 37% of those with ulcers.
    • Excluding Zollinger-Ellison syndrome cases, no significant differences in calcium, gastrin, or parathormone levels were observed between patients with and without ulcers.

    Conclusions:

    • Primary hyperparathyroidism is associated with a significantly high prevalence of peptic ulcer disease.
    • The underlying mechanisms linking hyperparathyroidism and peptic ulcer disease remain unclear.
    • Zollinger-Ellison syndrome is a notable comorbidity in a subset of these patients.