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Light-induced nitric oxide release from physiologically stable porous coordination polymers
Chiwon Kim1, Stéphane Diring, Shuhei Furukawa
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Dalton Transactions (Cambridge, England : 2003)
|July 31, 2015
Summary
Researchers developed stable porous materials that release nitric oxide (NO) on demand using light. These titanium-based porous coordination polymers (PCPs) show promise for biomedical applications requiring controlled NO delivery.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Nitric oxide (NO) releasing materials are crucial for cell biology and biomedicine.
- Porous materials offer a platform for hosting NO-releasing molecules.
- Existing NO-releasing scaffolds often involve macromolecular structures.
Purpose of the Study:
- To synthesize novel porous coordination polymers (PCPs) capable of controlled nitric oxide (NO) release.
- To introduce photoactive N-nitrosamine functional groups into PCP frameworks for NO donation.
- To evaluate the stability and NO release characteristics of titanium and aluminum-based PCPs.
Main Methods:
- Synthesis of amine-functionalized porous coordination polymers (PCPs).
- Post-synthetic nitrosation to introduce N-nitrosamine photoactive NO donors.
- Demonstration of light-controlled NO release.
- Assessment of framework stability in water and cell culture media.
Main Results:
- Successfully synthesized PCPs incorporating N-nitrosamine groups for photoactive NO release.
- Demonstrated controlled NO release triggered by light irradiation.
- Titanium-based PCPs exhibited superior stability in physiological conditions compared to aluminum analogues.
- Aluminum frameworks showed limited stability in aqueous and physiological environments.
Conclusions:
- Developed stable, light-responsive porous coordination polymers for nitric oxide delivery.
- Titanium-based PCPs are promising candidates for biomedical applications due to their enhanced stability.
- The study highlights the potential of functionalized porous materials for controlled therapeutic agent release.
