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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Relation between low 50-g glucose challenge test results and small-for-gestational-age infants

Satoshi Shinohara1, Mitsuo Hirai1, Shuji Hirata2

  • 1Department of Obstetrics and Gynecology, Kofu Municipal Hospital, Kofu.

The Journal of Obstetrics and Gynaecology Research
|August 1, 2015
PubMed

Insights

Low glucose challenge test (GCT) results are significantly linked to a higher risk of delivering small-for-gestational-age (SGA) infants. This finding suggests a potential connection that warrants further investigation into underlying mechanisms.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Endocrinology

Background:

  • The relationship between low 50-g glucose challenge test (GCT) results and the incidence of small-for-gestational-age (SGA) infants lacks a clear consensus.
  • Existing research has not definitively established whether lower-than-average GCT scores predict SGA births.

Purpose of the Study:

  • To investigate the association between low 50-g GCT results and SGA.
  • To adjust for potential confounding factors in a large clinical dataset to clarify this relationship.

Main Methods:

  • A retrospective cohort study was conducted using obstetric records from Kofu Municipal Hospital (January 2011-December 2013).
  • 1603 women with GCT results between 24-28 weeks of gestation were included, excluding those with gestational diabetes or GCT ≥140 mg/dL.
  • Subjects were categorized into a low-GCT group (≤90 mg/dL) and a non-low-GCT group (91-139 mg/dL).
  • Statistical analyses included the chi-squared test and multivariate logistic regression.

Main Results:

  • The incidence of SGA was 10.7% (172/1603) among the study population.
  • 17.9% (287/1603) of women presented with low GCT results.
  • Low GCT results were significantly associated with an increased risk of SGA (OR, 1.66; 95% CI, 1.14-2.42) after adjusting for maternal age, pre-pregnancy weight, weight gain, and pregnancy-induced hypertension.

Conclusions:

  • A significant association exists between low 50-g GCT results and the occurrence of SGA.
  • Further research is necessary to elucidate the specific biological mechanisms underlying this observed association.
Abstract

Keywords:
glucose challenge testmaternal weightpregnancy outcomescreeningsmall for gestational age

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