Related Experiment Video
Updated: Apr 6, 2026
11:38
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
Published on: July 3, 2014
47.6K
Comparative dosimetric findings using accelerated partial breast irradiation across five catheter subtypes
Zaker Rana1, Nadim M Nasr2, Huaying Ji3
1Department of Radiation Oncology, Virginia Hospital Center, 1701 N George Mason Dr, Arlington, VA, 22205, USA. zhrana88@gmail.com.
Radiation Oncology (London, England)
|August 1, 2015
Summary
Accelerated partial breast irradiation (APBI) using strut-based SAVI devices shows better skin and rib dose control compared to balloon-based methods. Understanding planning target volume (PTV) factors can optimize tumor control and minimize toxicity in APBI.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Accelerated partial breast irradiation (APBI) is a widely used treatment for early-stage breast cancer.
- Various brachytherapy devices, including balloon and strut-adjusted volume implants (SAVI), are employed for APBI delivery.
- Optimizing dose distribution and minimizing toxicity are crucial for improving patient outcomes in APBI.
Purpose of the Study:
- To evaluate the factors influencing skin dose, rib dose, and D95 coverage in patients undergoing brachytherapy-based APBI.
- To compare the dosimetric characteristics of different brachytherapy applicator subtypes used in APBI.
- To identify predictors of toxicity and tumor control in APBI patients.
Main Methods:
- Retrospective analysis of 594 patients treated with brachytherapy-based APBI.
- Patients were grouped by applicator subtype: SAVI, SAVI-mini, and multi-lumen balloons.
- Dosimetric parameters including DmaxSkin, DmaxRib, D90, D95, V150, and V200 were analyzed in relation to planning target volume (PTV).
Main Results:
- SAVI devices demonstrated the lowest DmaxSkin and highest D90/D95 values.
- SAVI-mini devices showed the lowest DmaxRib and V150.
- Strut-based applicators were more effective in meeting skin and rib dose constraints compared to balloon-based applicators.
- Planning target volume (PTV) was strongly correlated with V150 and V200, and weakly negatively correlated with DmaxSkin and DmaxRib.
Conclusions:
- Planning target volume (PTV) is a significant predictor of dose-volume parameters (V150, V200) and potential toxicity in APBI.
- Strut-based applicators offer superior skin and rib dose sparing compared to balloon-based devices.
- Understanding these dosimetric factors can aid in predicting patient outcomes and optimizing APBI treatment planning.
