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New advances in genitourinary cancer: evidence gathered in 2014

C Suárez1, J Puente2, E Gallardo3

  • 1Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain.

Cancer Metastasis Reviews
|August 1, 2015
PubMed

Insights

This 2014 review highlights key advances in genitourinary cancers, including prostate, renal, and bladder cancers, and germ cell tumors. It covers new treatments, molecular research, and clinical trial outcomes for improved patient care.

Area of Science:

  • Oncology
  • Urology
  • Genitourinary Cancer Research

Background:

  • Genitourinary cancers represent a significant global health burden.
  • Continuous research is vital for improving treatment strategies and patient outcomes.

Purpose of the Study:

  • To review significant advancements in genitourinary cancer research published in 2014.
  • To consolidate key findings in prostate, renal, bladder, and germ cell tumors.

Main Methods:

  • Literature review of scientific publications from 2014.
  • Synthesis of data on treatment approaches, molecular research, and clinical trials.

Main Results:

  • Updates on hormone-sensitive and castrate-resistant prostate cancer treatments, including new drugs and resistance mechanisms.
  • Advances in advanced renal cell carcinoma treatment, immunotherapy, and molecular research (angiogenesis, VHL gene, epigenetics).
  • New strategies for muscle-invasive bladder cancer and metastatic disease, alongside urothelial cancer biomolecular findings and metastatic germ cell cancer outcomes.

Conclusions:

  • Significant progress was made in 2014 across various genitourinary cancers.
  • Emerging molecular research and novel therapeutic strategies offer promise for improved patient management.
Keywords:
Bladder cancerGenitourinary cancerGerm cell tumorsMolecular researchProstate cancerRenal cancer

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