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Updated: Apr 6, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Psychopathological comorbidities in medication-overuse headache: a multicentre clinical study
P Sarchielli1, I Corbelli1, P Messina2
1Clinica Neurologica, Azienda Ospedaliero - Universitaria di Perugia, Perugia, Italy.
European Journal of Neurology
|August 1, 2015
Summary
Medication-overuse headache (MOH) patients exhibit more psychopathological comorbidities than episodic migraine (EM) patients or healthy controls (HC). Assessing these disorders is crucial for effective MOH treatment and management.
Area of Science:
- Neurology
- Psychiatry
- Clinical Psychology
Background:
- Medication-overuse headache (MOH) is a complex condition.
- Psychopathological disturbances are suspected predictors of MOH relapse and treatment resistance.
Purpose of the Study:
- To determine the prevalence of psychopathological disorders in MOH patients.
- To compare psychopathological profiles between MOH, episodic migraine (EM), and healthy controls (HC).
Main Methods:
- Utilized validated questionnaires: Beck Depression Inventory, Beck Anxiety Inventory, M-MINI, Y-BOCS, and Leeds Dependence Questionnaire.
- Assessed psychopathology in 88 MOH patients, 129 EM patients, and 102 HC subjects.
Main Results:
- MOH patients showed significantly higher rates of moderate/severe anxiety compared to EM and HC groups.
- MOH patients presented a more complex psychiatric comorbidity profile.
- Obsessive-compulsive disturbances related to drug abuse were more prevalent in MOH patients than in EM or HC groups.
Conclusions:
- Psychopathological comorbidities are frequently observed in MOH patients.
- Routine assessment of psychopathological profiles in MOH patients is recommended.
- Integrating behavioral treatments can significantly improve MOH management.
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