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Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
Published on: May 18, 2020
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Bioreactor control improves bioprocess performance.
Rimvydas Simutis1, Andreas Lübbert2
1Department of Automation, Kaunas University of Technology, Kaunas, Lithuania.
Biotechnology Journal
|August 1, 2015
Summary
Implementing feedback control in bioreactors significantly enhances fermentation process quality and product reproducibility. Simple feedback techniques can replace open-loop methods, improving industrial cultivation with minimal equipment changes.
Area of Science:
- Biotechnology
- Process Engineering
- Industrial Microbiology
Background:
- Bioreactor performance relies on productivity and process quality, influenced by process variable variances.
- Variations in process variables directly impact product properties, making distortion control crucial for quality assurance.
Purpose of the Study:
- To demonstrate that feedback control significantly improves fermentation process performance.
- To highlight the potential of simple feedback techniques to replace open-loop control in industrial settings.
Main Methods:
- Literature review of existing evidence on feedback control in fermentation.
- Analysis of practical examples showcasing retrofitting of feedback control systems.
- Comparison of feedback control with traditional open-loop procedures.
Main Results:
- Feedback control substantially enhances fermentation process performance and product reproducibility.
- Simple feedback techniques can be implemented with minimal changes to existing bioreactor equipment.
- Feedback control ensures consistent quality of products from industrial cultivation processes.
Conclusions:
- Feedback control is essential for assuring high reproducibility and quality in industrial fermentation.
- Developments in fermentation control can be applied to broader manufacturing processes.
- Adoption of automatic feedback control by manufacturers is recommended to improve process quality.
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