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Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy

Luciana Mazzei1,2, Neil G Docherty3, Walter Manucha4,5

  • 1Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. lucimazzei@hotmail.com.

Cell Stress & Chaperones
|August 1, 2015
PubMed

Insights

Heat shock protein 70 (Hsp70) is a key stress response in acute kidney injury. Its activation protects kidney cells from damage and inflammation, offering potential therapeutic benefits.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Urinary heat shock protein 70 (Hsp70) increases with acute kidney injury, signaling endogenous renal stress.
  • Hsp70 activation is linked to cytoprotective effects of drugs in experimental obstructive nephropathy models.

Purpose of the Study:

  • To review the biological actions of Hsp70 in renal cytoprotection during obstructive injury.
  • To explore Hsp70's role in the mechanism of action of drugs used in experimental obstructive nephropathy.

Main Methods:

  • Literature review of basic studies and experimental models.
  • Analysis of Hsp70's biological activities and their effects on renal cells.

Main Results:

  • Hsp70 exhibits cytoprotective effects through inhibiting apoptosis and inflammation.
  • Hsp70 aids in protein repair, prevents aggregation, targets damaged proteins for degradation, and stabilizes the cytoskeleton.

Conclusions:

  • Hsp70 plays a significant role in protecting kidney cells from injury in obstructive nephropathy.
  • Hsp70 is a potential central mechanism for various drugs that ameliorate experimental obstructive nephropathy.
Keywords:
ApoptosisHeat shock protein 70InflammationNitric oxideObstructive nephropathyWT-1

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