Related Experiment Video

Updated: Aug 17, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

[Disorders of blood coagulation and microcirculation in diabetics]

S I Titova, G I Kozlov, R M Mamedgasanov

    Problemy Endokrinologii
    |November 1, 1989
    PubMed

    Insights

    Chronic DIC-syndrome in diabetes mellitus can be diagnosed using blood coagulation tests. These tests detect microcirculatory disorders and platelet changes before clinical symptoms appear, aiding early intervention.

    Area of Science:

    • Hematology
    • Endocrinology
    • Vascular Biology

    Background:

    • Diabetes mellitus is associated with an increased risk of thrombotic complications.
    • Chronic disseminated intravascular coagulation (DIC) syndrome can occur in patients with diabetes mellitus.
    • Microvascular complications, such as retinopathy and nephropathy, are common in diabetes.

    Purpose of the Study:

    • To evaluate the utility of coagulation tests for diagnosing chronic DIC-syndrome in diabetes mellitus.
    • To investigate the relationship between coagulation parameters, microcirculatory disorders, and clinical symptoms in diabetic patients.
    • To determine if coagulation indices can predict the development of microangiopathy.

    Main Methods:

    • Assessment of platelet aggregation and disaggregation.
    • Analysis of coagulogram indices including fibrinogen and soluble fibrin-monomer complexes.
    • Measurement of fibrinolytic activity.
    • Conjunctival biomicroscopy to assess microcirculation.
    • Correlation analysis between coagulation parameters and clinical findings.

    Main Results:

    • Chronic DIC-syndrome was diagnosed in diabetic patients using platelet function tests and coagulogram indices.
    • DIC-syndrome was observed in diabetic patients prior to the onset of clinical microangiopathy symptoms.
    • Microcirculatory disorders, detected by conjunctival biomicroscopy, were concurrent with DIC-syndrome.
    • Platelet aggregation indices correlated with conjunctival microcirculation findings, even before diabetic retinopathy manifested clinically.

    Conclusions:

    • Coagulation tests, including platelet function and specific coagulogram indices, are recommended for diagnosing chronic DIC-syndrome in diabetes mellitus.
    • Chronic DIC-syndrome in diabetes mellitus precedes clinical microangiopathy and is associated with microcirculatory dysfunction.
    • Platelet aggregation monitoring may serve as an early indicator of microvascular changes in diabetic patients.

    More Related Videos

    Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo10:39

    Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

    Published on: March 8, 2018

    Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans08:21

    Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

    Published on: July 21, 2023

    Related Concept Videos

    Disorders of Hemostasis01:24

    Disorders of Hemostasis

    Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
    Thromboembolic Disorders
    Two factors primarily cause thromboembolic conditions.
    Complications of Diabetes Mellitus01:22

    Complications of Diabetes Mellitus

    Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
    Diabetic Foot Ulcer01:31

    Diabetic Foot Ulcer

    Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
    Diabetic Retinopathy01:27

    Diabetic Retinopathy

    DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
    Diabetic Neuropathy01:22

    Diabetic Neuropathy

    DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...