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Familial risk of pediatric chronic rhinosinusitis

Quinn Orb1, Karen Curtin2,3, Gretchen M Oakley1

  • 1Division of Otolaryngology, University of Utah School of Medicine.

The Laryngoscope
|August 1, 2015
PubMed

Insights

Children with chronic rhinosinusitis (CRS) have a significantly increased risk of developing the condition if they have affected relatives. This familial link suggests a genetic component to CRS, warranting further research into its causes.

Area of Science:

  • Otolaryngology
  • Genetics
  • Epidemiology

Background:

  • Chronic rhinosinusitis (CRS) is a common condition affecting both children and adults.
  • The etiology of CRS is complex, involving genetic predisposition and environmental factors.
  • Understanding familial risk can provide insights into the underlying causes of CRS.

Purpose of the Study:

  • To investigate the familial risk of developing chronic rhinosinusitis (CRS) in relatives of pediatric patients diagnosed with CRS.
  • To quantify the recurrence risk across different degrees of familial relationship.

Main Methods:

  • Retrospective observational cohort study utilizing a unique genealogical database linked to medical records.
  • Identified pediatric CRS cases (≤12 years old) from 1996-2011.
  • Calculated familial recurrence risks using Cox models and compared them to population-based matched controls.

Main Results:

  • Siblings of pediatric CRS patients showed a 57.5-fold increased risk of also having pediatric CRS.
  • First cousins had a 9.0-fold increased risk, and second cousins had a 2.9-fold increased risk.
  • First-degree and second-degree relatives, including parents, demonstrated a significantly increased risk of adult CRS.

Conclusions:

  • A significant familial risk for chronic rhinosinusitis (CRS) is confirmed in the largest population study to date.
  • Increased risk in parents suggests a genetic component, though one affected parent was more common than two.
  • Further research into the genetic basis and environmental interactions of CRS is needed for targeted treatments.
Abstract

Keywords:
Pediatric chronic rhinosinusitisfamilial riskgeneticsnasal polyposis

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