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Updated: Apr 6, 2026

Physiological Preparation of Hair Cells from the Sacculus of the American Bullfrog Rana catesbeiana
Published on: March 17, 2017
Assembly of hair bundles, an amazing problem for cell biology
1Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239 gillespp@ohsu.edu.
Abstract:
The hair bundle--the sensory organelle of inner-ear hair cells of vertebrates--exemplifies the ability of a cell to assemble complex, elegant structures. Proper construction of the bundle is required for proper mechanotransduction in response to external forces and to transmit information about sound and movement. Bundles contain tightly controlled numbers of actin-filled stereocilia, which are arranged in defined rows of precise heights. Indeed, many deafness mutations that disable hair-cell cytoskeletal proteins also disrupt bundles. Bundle assembly is a tractable problem in molecular and cellular systems biology; the sequence of structural changes in stereocilia is known, and a modest number of proteins may be involved.
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