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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Aterofisiol(®) in carotid plaque evolution.

Bruno Amato1, Rita Compagna1, Maurizio Amato2

  • 1Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

Drug Design, Development and Therapy
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Summary
This summary is machine-generated.

Aterofisiol, a supplement with omega-3s and vitamins, reduced plaque lipids and neurological symptoms in carotid stenosis patients. This study highlights its potential in managing atherosclerotic plaque composition.

Keywords:
Aterofisiol®carotid plaquecarotid stenosischolesterolendarterectomyneurological symptoms

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Area of Science:

  • Cardiovascular Research
  • Nutritional Science
  • Surgical Innovation

Background:

  • Carotid stenosis risk is linked to atherosclerotic plaque composition, not just size.
  • Understanding plaque composition is crucial for managing rupture risk.
  • Aterofisiol is a supplement containing omega-3 fatty acids (EPA/DHA), vitamin K2, B6, B12, OPC, and resveratrol.

Purpose of the Study:

  • To evaluate Aterofisiol's impact on atherosclerotic plaque composition.
  • To assess Aterofisiol's effect on neurological symptoms in carotid stenosis patients undergoing endarterectomy.

Main Methods:

  • Randomized, prospective, double-blind study design.
  • 214 patients with >70% carotid stenosis undergoing endarterectomy were enrolled.
  • Patients received either acetylsalicylic acid + Aterofisiol or acetylsalicylic acid + placebo for 30 days pre-surgery.

Main Results:

  • Mean lipid content in removed plaques was significantly lower in the Aterofisiol group (P<0.05).
  • A significantly lower incidence of neurological symptoms was observed in the Aterofisiol group (P<0.05).
  • 94.4% of enrolled patients completed the study protocol.

Conclusions:

  • Aterofisiol effectively reduced cholesterol and lipid content in atherosclerotic plaques.
  • Aterofisiol demonstrated efficacy in reducing adverse neurological events compared to placebo.
  • The findings suggest Aterofisiol's therapeutic potential in managing carotid stenosis.