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Single molecular recognition force spectroscopy study of a DNA aptamer with the target epithelial cell adhesion
Nan Wang1, Huiqing Liu, Jinhui Hao
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China. jltang@ciac.ac.cn.
The Analyst
|August 1, 2015
Abstract:
The epithelial cell adhesion molecule (EpCAM) is a tumor-specific antigen for malignancies of the epithelialis lineage. In this study the interaction between the DNA-based EpCAM aptamer (SYL3C) and EpCAM was explored using single molecular recognition force spectroscopy (SMFS). The capability of aptamer SYL3C to recognize the EpCAM protein and the kinetic parameters were investigated.
