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Hepatitis C virus infection and kidney transplantation: newer options and a brighter future ahead?

David Del Bello1, Michael J Ross1, Shirish S Huprikar1

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Kidney International
|August 1, 2015
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to poorer outcomes for kidney transplant patients, even those with HIV. New, effective HCV treatments offer improved options for these individuals.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection poses risks to kidney transplant recipients.
  • Outcomes in kidney transplant recipients with HCV, with or without HIV, require further investigation.

Purpose of the Study:

  • To analyze the impact of HCV infection on kidney transplant recipients.
  • To discuss the implications of HCV treatment advancements in this patient population.

Main Methods:

  • Review of recent studies, including Sawinski et al.
  • Commentary on the significance of findings in the context of current treatment options.

Main Results:

  • HCV infection is associated with worse outcomes in kidney transplant recipients.
  • This association is observed in both HIV-positive and HIV-negative patients.

Conclusions:

  • HCV infection negatively impacts kidney transplant outcomes.
  • Emerging HCV therapies present improved efficacy and safety profiles for kidney transplant candidates and recipients.

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