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Related Experiment Videos

One trial conditioning with apomorphine is blocked by cycloheximide.

P B Silverman1, N P Baruch, K A Schultz

  • 1University of Texas Medical School, Department of Psychiatry-MSI, Houston 77030.

Pharmacology, Biochemistry, and Behavior
|November 1, 1989
PubMed
Summary

Cycloheximide, a protein synthesis inhibitor, blocks the formation of long-term memory for conditioned rotation in rats. However, this effect is reversible, as memory is restored after a second apomorphine treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Unilateral 6-hydroxydopamine lesions in rats create an animal model for Parkinson's disease, inducing circling behavior.
  • Apomorphine is a dopamine agonist used to study motor control and behavioral responses in lesioned animals.
  • Protein synthesis is crucial for long-term memory consolidation.

Purpose of the Study:

  • To investigate the role of protein synthesis in the formation of long-term memory for conditioned rotation.
  • To determine if cycloheximide, a protein synthesis inhibitor, affects the consolidation of learned motor behaviors.

Main Methods:

  • Rats with unilateral substantia nigra lesions were administered apomorphine to induce circling behavior.
  • Cycloheximide or saline was administered after apomorphine to assess its effect on memory formation.

Related Experiment Videos

  • Conditioned rotation behavior was tested after a two-week period and again after a second apomorphine administration.

    • Main Results:

    • Animals treated with cycloheximide did not exhibit conditioned rotation two weeks after the initial treatment.
    • Control animals (saline-treated) showed significant conditioned rotation.
    • Both groups displayed conditioned rotation after a second apomorphine administration, indicating memory recovery.

    Conclusions:

    • Protein synthesis is essential for the long-term consolidation of conditioned motor behaviors.
    • Inhibition of protein synthesis by cycloheximide temporarily disrupts memory formation for learned behaviors.
    • The findings highlight the dynamic nature of memory consolidation and potential for recovery.