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In vivo interactions of NAN-190, a putative selective 5-HT1A antagonist, with ipsapirone
C Deans1, M Leathley, A Goudie
1Department of Psychology, University of Liverpool, U.K.
Pharmacology, Biochemistry, and Behavior
|December 1, 1989
Abstract:
The actions of NAN-190, a putative 5-HT1A antagonist, were assessed in rats. The selective 5-HT1A agent ipsapirone suppressed operant responding, but this effect was not antagonised by NAN-190, which suppressed responding itself in a dose-related manner, and had additive effects when administered with ipsapirone. These data do not support suggestions that NAN-190 is a 5-HT1A antagonist. NAN-190 may be a 5-HT1A partial agonist which can antagonise effects of full 5-HT1A agonists.