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Amyloidosis: Modern Cross-sectional Imaging.

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Amyloidosis, a condition of abnormal protein buildup, presents diverse and nonspecific radiologic findings. This review details thoracic and cardiac manifestations across imaging modalities, aiding diagnosis.

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Area of Science:

  • Radiology
  • Pathology
  • Internal Medicine

Background:

  • Amyloidosis involves abnormal protein deposition, leading to diverse systemic conditions.
  • It can be primary, secondary to other diseases, or hereditary, with over two dozen subtypes.
  • Radiologic findings are often nonspecific, posing diagnostic challenges.

Purpose of the Study:

  • To review the pathophysiology, classification, treatment, and prognosis of amyloidosis.
  • To illustrate the varied radiologic manifestations of thoracic and cardiac amyloidosis.
  • To aid radiologists in diagnosing amyloidosis through characteristic imaging findings.

Main Methods:

  • Review of existing literature on amyloidosis pathophysiology and classification.
  • Analysis of radiologic appearances in chest radiographs, CT, and cardiac MR imaging.
  • Presentation of case examples for thoracic and cardiac amyloidosis.

Main Results:

  • Amyloidosis affects multiple organ systems, including the chest (lungs, pleura, airways, mediastinum) and heart.
  • Radiologic findings include interstitial thickening, nodules, pleural effusions, airway abnormalities, enlarged lymph nodes, and cardiac abnormalities.
  • Cardiac MR imaging shows left ventricular thickening and characteristic enhancement patterns.

Conclusions:

  • Amyloidosis presents a diagnostic challenge due to nonspecific imaging findings.
  • Recognizing characteristic patterns on chest and cardiac imaging is crucial for diagnosis.
  • Comprehensive understanding of amyloidosis imaging aids in timely patient management.