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Association of branched-chain amino acids with coronary artery disease: A matched-pair case-control study

R Y Yang1, S M Wang1, L Sun1

  • 1The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|August 2, 2015
PubMed

Insights

Higher levels of branched-chain amino acids (BCAAs) are significantly associated with an increased risk of coronary artery disease (CAD). This finding highlights BCAAs as potential biomarkers for cardiovascular event risk.

Area of Science:

  • Cardiovascular Science
  • Metabolic Research
  • Biomarker Discovery

Background:

  • Plasma branched-chain amino acids (BCAAs) have shown associations with coronary artery disease (CAD) risk factors.
  • Limited research exists on the direct link between BCAAs, CAD, and cardiovascular event risk.

Purpose of the Study:

  • To investigate the relationship between plasma BCAA levels and the presence of CAD.
  • To determine if BCAAs are independent predictors of CAD.

Main Methods:

  • A case-control study involving 143 CAD patients and 286 healthy controls matched by age and gender.
  • Conditional logistic regression models were used for statistical analysis.
  • Multivariate adjustments were made for traditional CAD risk factors.

Main Results:

  • A one-standard-deviation increase in BCAA concentration was associated with a nearly twofold increased risk of CAD (OR=1.63, P=0.001) after adjustment.
  • Individuals in the highest quartile of BCAA levels had a significantly higher risk of CAD compared to the lowest quartile (OR=3.86, P trend=0.01).

Conclusions:

  • Plasma BCAAs are significantly associated with the development of CAD.
  • The relationship between BCAAs and CAD is independent of common risk factors like diabetes, hypertension, dyslipidemia, and BMI.
Abstract

Keywords:
Branched-chain amino acidsCase–control studyCoronary artery diseaseOdds ratioRisk factor

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