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Repeatability of Central and Peripheral Pulse Wave Velocity Measures: The Atherosclerosis Risk in Communities (ARIC)

Michelle L Meyer1, Hirofumi Tanaka2, Priya Palta3

  • 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; mlmeyer@unc.edu.

American Journal of Hypertension
|August 2, 2015
PubMed

Insights

Repeatability of pulse wave velocity (PWV) measures, including carotid-femoral (cfPWV), brachial-ankle (baPWV), and femoral-ankle (faPWV), is acceptable for epidemiologic studies and clinical practice. Quantifying measurement variation is crucial for risk assessment in cardiovascular disease.

Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Epidemiology

Background:

  • Arterial stiffness is increasingly used for cardiovascular disease (CVD) risk assessment.
  • Carotid-femoral pulse wave velocity (cfPWV) measures central arterial stiffness.
  • Other measures include femoral-ankle (faPWV) for peripheral stiffness and brachial-ankle (baPWV) for composite stiffness.

Purpose of the Study:

  • To compare the repeatability of central, peripheral, and composite pulse wave velocity (PWV) measures.
  • To evaluate the reliability of cfPWV, faPWV, and baPWV in a population-based study.

Main Methods:

  • Seventy-nine older adults (mean age 75.7 years) from the ARIC study underwent two standardized visits.
  • Two PWV measurements (cfPWV, faPWV, baPWV) were taken at each visit using the VP-1000 Plus system.
  • Intraclass correlation coefficients (ICCs), minimal detectable change (MDC95), and minimal detectable difference (MDD) were calculated.

Main Results:

  • Intraclass correlation coefficients (ICCs) were 0.70 for cfPWV, 0.84 for baPWV, and 0.69 for faPWV.
  • MDC95 values were 411.0 cm/s (cfPWV), 370.6 cm/s (baPWV), and 301.4 cm/s (faPWV).
  • MDD values were 139.3 cm/s (cfPWV), 172.3 cm/s (baPWV), and 100.4 cm/s (faPWV).

Conclusions:

  • Repeatability of all PWV measures (cfPWV, baPWV, faPWV) was acceptable in this older adult population.
  • Findings support the use of these PWV measures in epidemiologic studies and for clinical risk stratification.
  • Quantifying measurement variation is essential for accurate CVD risk assessment and clinical application.
Abstract

Keywords:
arterial stiffnessblood pressurecentral arterial stiffnesshypertensionperipheral arterial stiffnessreliabilityreproducibilitysubclinical cardiovascular disease.

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