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Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the

Martine Morzel1, Eric Neyraud1, Hélène Brignot1

  • 1CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France; Université de Bourgogne, UMR Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.

Journal of Proteomics
|August 2, 2015
PubMed

Insights

Children with long-term eating difficulties (ED) show altered saliva composition, including lower antioxidant status and protease inhibitors. This highlights the crucial role of oral stimulation from eating in maintaining oral health.

Area of Science:

  • Oral physiology
  • Pediatric nutrition
  • Biochemistry

Background:

  • Prolonged enteral/parenteral nutrition can lead to persistent eating difficulties (ED) in children.
  • Reduced oral intake diminishes oral cavity stimulation, potentially impacting oral physiology.

Purpose of the Study:

  • To investigate the impact of reduced oral stimulation on saliva composition in children with ED.
  • To compare salivary profiles between children with ED and healthy controls.

Main Methods:

  • Utilized multi-omics and targeted methods to analyze saliva from 21 children with ED and 23 healthy controls.
  • Employed spectral methods including MALDI-TOF, SELDI-TOF, and (1)H NMR for saliva analysis.

Main Results:

  • Spectral methods successfully differentiated saliva composition between ED patients and controls.
  • ED patients exhibited a lower antioxidant status and reduced levels of salivary cystatins.
  • Discriminant salivary features like IgA1 and dimethylamine suggest altered oral/intestinal microbial ecology.

Conclusions:

  • Oral stimulation from food intake significantly influences saliva composition.
  • Altered salivary profiles in ED patients may be linked to reduced oral stimulation and potentially exacerbated gustatory sensitivities.
  • Further research is needed to explore the connection between salivary changes, taste hypersensitivity, and eating difficulties.

Keywords:
ChildrenFeeding difficultiesProfilingSalivaTube feeding

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