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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Related Experiment Video

Updated: Apr 6, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
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Microenvironment abnormalities and lymphomagenesis: Immunological aspects.

Joseph G Taylor1, John G Gribben1

  • 1Barts Cancer Institute, Queen Mary University of London, UK.

Seminars in Cancer Biology
|August 2, 2015
PubMed
Summary
This summary is machine-generated.

The immune system

Keywords:
AnergyCD8CytotoxicIL-10ImmunosurveillanceLymphomagenesisMicroenvironmentNKG2DNatural killerPD-1RegulatoryTGFβTumorigenesis

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Area of Science:

  • Immunology
  • Cancer Biology
  • Oncology

Background:

  • Immune cells like Natural Killer (NK) cells and Cytotoxic T Lymphocytes (CTL) normally detect and destroy pre-cancerous cells.
  • Cancer develops when tumors evade these immune responses through various mechanisms.

Purpose of the Study:

  • To review the mechanisms by which the tumor microenvironment promotes lymphomagenesis.
  • To understand how immune evasion contributes to cancer development.

Main Methods:

  • Literature review of mechanisms of immune evasion in cancer.
  • Analysis of how altered immune cell function and tumor signaling impact cancer progression.

Main Results:

  • Tumors can escape immune detection by altering ligand expression or becoming resistant to immune cell attack.
  • Immune tolerance mechanisms can compromise the activity of NK cells and CTLs.
  • These immune escape strategies are critical for cancer development.

Conclusions:

  • Alterations in the immune microenvironment are key drivers of lymphomagenesis.
  • Understanding these mechanisms is crucial for developing effective cancer immunotherapies.