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Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
479

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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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Phase-based vascular input function: Improved quantitative DCE-MRI of atherosclerotic plaques.

R H M van Hoof1, E Hermeling1, M T B Truijman2

  • 1Department of Radiology, Maastricht University Medical Center, Maastricht 6202 AZ, The Netherlands and CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht 6200 MD, The Netherlands.

Medical Physics
|August 3, 2015
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Summary

Phase-based vascular input functions (ph-VIF) are recommended for dynamic contrast-enhanced MRI of carotid plaques. Magnitude-based VIF (m-VIF) is significantly affected by blood flow, leading to underestimation of contrast concentration.

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Area of Science:

  • Cardiovascular Imaging
  • Biomedical Engineering
  • Radiology

Background:

  • Quantitative pharmacokinetic modeling of dynamic contrast-enhanced (DCE)-MRI assesses atherosclerotic plaque microvasculature.
  • Plaque microvasculature is a key indicator of plaque vulnerability.

Purpose of the Study:

  • To compare magnitude-based vascular input functions (m-VIF) versus phase-based vascular input functions (ph-VIF) in pharmacokinetic modeling.
  • To gain insight into the differences between m-VIF and ph-VIF through model calculations and flow phantom experiments.

Main Methods:

  • Acquired population-averaged m-VIF and ph-VIFs from 11 patients with carotid plaques.
  • Performed pharmacokinetic analysis in 17 additional patients.
  • Conducted simulations using Bloch equations and flow phantom experiments to assess the impact of blood velocity on signal enhancement.

Main Results:

  • Simulations and phantom experiments showed that lumen flow severely underestimates m-VIF but not ph-VIF.
  • In vivo, peak m-VIF concentration was significantly lower than ph-VIF (p < 0.001).
  • Quantitative model parameters (K(trans), vp) derived from m-VIF and ph-VIF were moderately to strongly correlated.

Conclusions:

  • Local blood velocity significantly influences m-VIF, causing underestimation of contrast agent concentration.
  • ph-VIF is recommended for accurate DCE-MRI analysis of carotid plaques.