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Genetic Screens02:46

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Related Experiment Video

Updated: Apr 6, 2026

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Attitudes Toward Genetic Testing for Celiac Disease.

Abhik Roy1, Michele Pallai1, Benjamin Lebwohl1

  • 1Department of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavillion 180 Fort Washington Ave Room 936, New York, NY, 10032, USA.

Journal of Genetic Counseling
|August 3, 2015
PubMed
Summary

Genetic testing (GT) awareness is high among celiac disease (CD) support groups, particularly for those with higher education and children. Further education is recommended for individuals with lower educational attainment.

Keywords:
AttitudesAwarenessCeliac diseaseEducationGenetic testingGeneticsHLAKnowledgeSupport groupsSurvey

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Area of Science:

  • Genetics
  • Gastroenterology
  • Public Health

Background:

  • Celiac disease (CD) diagnosis relies on human leukocyte antigen (HLA) molecular typing, a genetic test with high negative predictive value.
  • Understanding patient knowledge and attitudes towards genetic testing (GT) is crucial for effective implementation and counseling.

Purpose of the Study:

  • To explore awareness and attitudes towards genetic testing (GT) among members of celiac disease (CD) support groups in the United States.
  • To identify factors influencing awareness of GT availability for CD.

Main Methods:

  • A 25-item questionnaire was developed by a multidisciplinary team.
  • The survey was distributed to 1835 members of CD support groups across the United States.
  • Multivariable analysis was used to identify predictors of GT awareness.

Main Results:

  • Awareness of GT was high among respondents (n=1835).
  • College education (OR 2.05) and having children (OR 1.56) were significant predictors of GT awareness.
  • Most patients with a personal or family history of CD planned GT for their children, citing cost and insurance concerns.

Conclusions:

  • Awareness of genetic testing is generally high within celiac disease support communities.
  • Targeted educational efforts are needed to improve GT knowledge among individuals with lower educational levels.
  • Healthcare professionals should address patient concerns regarding the cost and insurance implications of genetic testing results.