Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.5K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.5K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

2.2K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
2.2K
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

2.0K
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
2.0K
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.2K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.2K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.3K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Food Oral Immunotherapy Patient Selection, Dosing, and Monitoring Practices Among a Network of US Food Allergy Centers.

The journal of allergy and clinical immunology. In practice·2026
Same author

Allergy is more than type 2 disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Authors' response.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Dupilumab versus placebo in adults and adolescents with eosinophilic gastritis (DEGAS): a double-blind, placebo-controlled, phase 2, multicentre, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026
Same author

Allergen Immunotherapy for the Treatment of Eosinophilic Esophagitis. An EAACI Task Force Systematic Review.

Clinical and translational allergy·2026
Same author

Safety and efficacy of three office-based egg oral immunotherapy protocols.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K

Eosinophilic Esophagitis and Gastroenteritis.

Antonella Cianferoni1, Jonathan M Spergel

  • 1Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA, 19104-4399, USA, cianferonia@email.chop.edu.

Current Allergy and Asthma Reports
|August 3, 2015
PubMed
Summary

Eosinophilic gastrointestinal diseases (EGID) encompass conditions like eosinophilic esophagitis (EoE), gastritis, and colitis. While EoE is common and treatable, other EGIDs are rare, poorly defined, and challenging to manage.

More Related Videos

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.5K
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.9K

Related Experiment Videos

Last Updated: Apr 6, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.6K
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.5K
Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.9K

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic gastrointestinal diseases (EGID) are a spectrum of conditions characterized by eosinophil infiltration in the GI tract.
  • Eosinophilic esophagitis (EoE) is the most prevalent form, recognized as a chronic atopic disease driven by Th2 inflammation and food allergens.
  • Other EGIDs, including eosinophilic gastritis (EG), eosinophilic colitis (EC), and eosinophilic gastroenteritis (EGE), present with varied characteristics and diagnostic challenges.

Purpose of the Study:

  • To differentiate between eosinophilic esophagitis (EoE) and other forms of eosinophilic gastrointestinal diseases (EGID), such as eosinophilic gastroenteritis (EGE), eosinophilic gastritis (EG), and eosinophilic colitis (EC).
  • To highlight the distinct diagnostic criteria, pathogenesis, and treatment approaches for EoE compared to other EGIDs.
  • To emphasize the rarity and diagnostic complexities of EGE, EG, and EC, often requiring exclusion of other hypereosinophilic conditions.

Main Methods:

  • Classification of EGID based on the location of eosinophilic infiltration within the gastrointestinal tract.
  • Review of diagnostic criteria, including biopsy findings (e.g., ≥15 eosinophils/hpf for EoE) and endoscopic evaluations.
  • Differential diagnosis considerations for hypereosinophilic conditions with GI involvement.

Main Results:

  • EoE is a well-defined, common Th2-mediated disease often triggered by food allergens, with established therapies like swallowed inhaled steroids and food avoidance.
  • EGE, EG, and EC are less common, present with non-specific GI symptoms, and have unclear pathogenesis, making diagnosis and treatment challenging.
  • EG shares Th2 inflammation characteristics with EoE but exhibits a distinct systemic gene signature, while EC varies from a benign infant allergy to a severe inflammatory condition in older individuals.

Conclusions:

  • EoE has established diagnostic and therapeutic guidelines, focusing on symptom control and complication prevention.
  • EGE, EG, and EC are often diagnoses of exclusion, requiring thorough differential diagnosis due to their rarity and poorly defined nature.
  • Further research is needed to elucidate the pathogenesis and establish standardized treatments for EGE, EG, and EC.