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Published on: January 7, 2018
Influence of dioxin on the daily variation of insulin sensitivity in mice
Masashi Takuma1, Kentaro Ushijima1, Masafumi Kumazaki1
1Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
Abstract:
To evaluate an influence of dioxin on a daily variation of insulin sensitivity, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (100ng/kg) was given for 3 weeks in mice. Insulin tolerance test and oral glucose tolerance test were performed. TCDD decreased insulin sensitivity at an active period, but not at a rest period. TCDD elevated plasma TNF-α, and the value was significantly higher during an active period than during a rest period. These data suggest that TCDD blunts insulin sensitivity, mainly during an active period. Higher elevation in plasma TNF-α during an active period might be involved in this phenomenon.
