[RESULTS OF RESEARCH OF GALECTIN-3 AND THYROGLOBULIN IN PATIENTS WITH THYROID NODULES].

Area of Science:

• Biochemistry
• Oncology
• Pathology

Context:

• Thyroid nodules are common, requiring accurate differentiation between benign and malignant types.
• Fine-needle aspiration biopsy (FNAB) is a standard diagnostic tool for thyroid nodules.
• Immunofluorescence assay (IFA) is utilized for detecting specific biomarkers.

Purpose:

• To investigate the diagnostic utility of galectin-3 and thyroglobulin in differentiating high differentiated thyroid carcinoma from benign thyroid nodules.
• To evaluate the potential of these proteins as oncological markers in thyroid aspirates.

Summary:

• An immunofluorescence assay (IFA) was performed on thyroid aspirates from 80 patients undergoing fine-needle aspiration biopsy.
• Significantly elevated levels of galectin-3 and thyroglobulin were observed in patients with high differentiated thyroid carcinoma compared to those with benign nodules.
• These findings suggest that galectin-3 and thyroglobulin in thyroid lavage aspirates can serve as valuable oncological markers.

Impact:

• This research provides a potential non-invasive method for improving the diagnostic accuracy of high differentiated thyroid carcinoma.
• The identified biomarkers could enhance the differential diagnosis between malignant and benign thyroid nodules, potentially leading to earlier and more appropriate patient management.
• This study contributes to the field of molecular diagnostics for thyroid cancer.