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The Structured Interview for Schizotypy (SIS): a preliminary report.

K S Kendler1, J A Lieberman, D Walsh

  • 1Dept. of Psychiatry, Medical College of Virginia, Richmond 23298.

Schizophrenia Bulletin
|January 1, 1989
PubMed
Summary

The Structured Interview for Schizotypy (SIS) is a new tool for assessing schizotypal symptoms and signs. It reliably distinguishes relatives of schizophrenia patients from controls in pilot studies.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Genetics

Background:

  • Schizotypal symptoms and signs are key indicators in schizophrenia spectrum disorders.
  • Existing interview instruments may lack comprehensive assessment of schizotypal traits.
  • A reliable and valid instrument is needed for research and clinical applications.

Purpose of the Study:

  • To introduce and validate the Structured Interview for Schizotypy (SIS), a novel interview-based instrument.
  • To assess the reliability and discriminative validity of the SIS for schizotypal symptoms and signs.

Main Methods:

  • Development of the SIS based on a large family study of schizophrenia.
  • Field-testing of the SIS in multiple locations.
  • Inclusion of built-in contextual assessments, multiple scored items, assessment of signs, and specific symptom probes.

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  • Evaluation of inter-rater reliability for symptoms and signs.
  • Pilot studies to assess the instrument's ability to discriminate relatives of schizophrenic patients from controls.

    • Main Results:

    • The SIS demonstrates high reliability in assessing schizotypal symptoms.
    • Schizotypal signs are reliably assessed by the SIS when variability is present, though with generally lower reliability than symptoms.
    • Three independent pilot studies showed the SIS significantly discriminates between relatives of schizophrenic patients and control relatives.

    Conclusions:

    • The Structured Interview for Schizotypy (SIS) is a reliable and valid instrument for assessing schizotypal symptoms and signs.
    • The SIS shows promise in differentiating individuals at clinical high risk for schizophrenia.
    • The instrument's design facilitates comprehensive assessment and may aid in early identification and research of schizotypal personality disorder.