Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

9.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.9K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

86
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
86
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.5K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.7K
1.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.1K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Buffalo rumen microbial cellulase as a candidate enzyme for hydrolysis of rice straw into glucose: A preliminary study.

Open veterinary journal·2026
Same author

Dynamic changes in the sperm quality of <i>Azolla pinnata</i> as a forage alternative to Garut ram.

Open veterinary journal·2026
Same author

Correction: Gut microbiota profile, potential engineering techniques and its genetic and epigenetic implications in poultry health.

World journal of microbiology & biotechnology·2026
Same author

Cognitive workload, perceived environmental noise, and alarm fatigue among multidisciplinary intensive care unit staff: A pre-intervention cross-sectional study.

Applied nursing research : ANR·2026
Same author

Anopheles ecology and serological evidence of malaria exposure in clinically malaria-free areas of Menoreh Hills Central Java, Indonesia.

Scientific reports·2026
Same author

Computational multi-omics modelling identifies TOP2A as a central prognostic biomarker and therapeutic target in renal cell carcinoma.

Archives of biochemistry and biophysics·2026

Related Experiment Video

Updated: Apr 6, 2026

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

7.7K

SUMOylation: A link to future therapeutics.

Faheem Ahmed Khan1, Nuruliarizki Shinta Pandupuspitasari, Chun-Jie Huang

  • 1Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.

Current Issues in Molecular Biology
|August 4, 2015
PubMed
Summary

SUMOylation, a process similar to ubiquitination, is a promising therapeutic target for infectious and cancerous diseases. This review explores its regulatory mechanisms, cross-talk with other modifications, and potential therapeutic applications.

More Related Videos

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
09:45

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

9.9K
Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

12.0K

Related Experiment Videos

Last Updated: Apr 6, 2026

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
08:29

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

7.7K
In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
09:45

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

9.9K
Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

12.0K

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • SUMOylation, a post-translational modification, is increasingly recognized for its role in various diseases.
  • Initially linked to viral infections, SUMOylation's involvement in bacterial diseases is now evident.
  • Understanding SUMOylation is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review the regulatory mechanisms of gene expression under disturbed SUMOylation pathways.
  • To explore the cross-talk between SUMOylation and other post-translational modifications.
  • To investigate the role of miRNAs and exosomal RNA loading in SUMOylation-related diseases and therapeutics.

Main Methods:

  • Literature review of recent studies on SUMOylation.
  • Analysis of gene regulatory mechanisms.
  • Examination of post-translational modification cross-talk.
  • Investigation of miRNA and exosome involvement.

Main Results:

  • SUMOylation pathway dysregulation impacts gene expression.
  • Complex cross-talk exists between SUMOylation and other post-translational modifications.
  • miRNAs and exosomes play significant roles in SUMOylation-mediated cellular processes.
  • Identification of potential SUMOylation-related therapeutic targets.

Conclusions:

  • SUMOylation is a critical regulator in various disease states.
  • Targeting SUMOylation pathways offers potential therapeutic avenues for infectious and cancerous diseases.
  • Further research into SUMOylation, miRNAs, and exosomes is warranted for therapeutic development.