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Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
Published on: April 30, 2019
Bleomycin pulmonary toxicity in adult Saudi patients with Hodgkin's lymphoma
Wafa'a A Al-Jizani1, Mubarak M Al-Mansour1, Turki M Al-Fayea1
1Princess Noorah Oncology Center, King Abdulaziz Medical City, PO BOX 9515, Jeddah 21423, Kingdom of Saudi Arabia.
Background:
Bleomycin pulmonary toxicity (BPT) has been described in Hodgkin's lymphoma (HL) patients treated with bleomycin-containing chemotherapy regimens.
Methodology:
We reviewed the records of 164 consecutive HL patients.
Results:
BPT was observed in 24 of 164 patients (15%). Older age and history of concomitant lung disease were significantly associated with approximately threefold (odds ratio: 3.38; 95% CI: 1.25-9.13; p = 0.02) and sevenfold (odds ratio: 7.19; 95% CI: 2.64-19.54; p < 0.0001) increase in BPT risk, respectively. The actuarial 5-year progression-free and overall survival for BPT and non-BPT groups, were not significantly different.
Conclusion:
In Saudi Arabian HL patients, the risk of BPT and its effect on survival outcome were comparable to that reported from developed countries.
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