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Updated: Apr 6, 2026

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice
Published on: January 24, 2025
The diverse roles of adiponectin in non-small-cell lung cancer: current data and future perspectives
Paraskevi Boura1, Stylianos Loukides1, Dimitra Grapsa1
1Oncology Unit GPP, 'Sotiria' General Hospital, Athens School of Medicine, Mesogion 152, 11527, Athens, Greece.
Abstract:
In recent years, there is growing research interest for the biological role of adipose tissue-derived bioactive factors, mainly including adipokines, in various forms of cancer. Adiponectin (APN) is the most abundant circulating adipokine, and a key mediator of several cancer-related processes, such as cell proliferation, apoptosis, regulation of tumor cell invasion and angiogenesis. In this review we summarize and critically discuss the published literature on the diverse roles of APN in non-small-cell lung cancer, including its implication in lung cancer development, its use as a diagnostic and prognostic biomarker, and its correlation with cancer-related cachexia. The main challenges and future perspectives, mainly with regard to the potential development of APN-targeted therapeutic agents in cancer therapeutics, are also briefly presented and discussed.
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