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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Randainins A-D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis
Ho-Hsi Cheng1, Yuan-Bin Cheng2, Tsong-Long Hwang3,4,5
1School of Pharmacy, College of Medicine, National Taiwan University , Taipei 100, Taiwan.
Abstract:
Four new compounds, randainins A-D (1-4), were isolated from the leaves and twigs of Callicarpa randaiensis, which is an endemic species in Taiwan. Compounds 1 and 2 are diterpenoids with an unusual trans-7/5 ring system, whereas compounds 3 and 4 are diterpenoids possessing a trans-5/7 ring scaffold. The structures of the new compounds were established based on NMR and MS data analyses. Anti-inflammatory activities and cytotoxicity were tested and evaluated for these compounds. Compound 4 exhibited moderate inhibition of superoxide-anion generation with an IC50 value of 21.5 ± 2.5 μM.
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