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Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

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Published on: December 8, 2015

NaOCl-mediated biofunctionalization enhances bone-titanium integration.

Mai Kono¹, Hideki Aita, Yuki Ichioka

¹Department of Oral Rehabilitation, Division of Occlusion and Removable Prosthodontics, Health Sciences University of Hokkaido.

Dental Materials Journal

|August 4, 2015

Summary

Sodium hypochlorite (NaOCl) pretreatment significantly improves bone-titanium integration strength in early healing stages. This simple chemical method enhances implant osseointegration for better dental and orthopedic applications.

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Last Updated: Apr 6, 2026

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

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Published on: December 8, 2015

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

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Published on: September 11, 2015

Area of Science:

Biomaterials Science
Orthopedic Surgery
Dental Implantology

Background:

Osseointegration is crucial for dental and orthopedic implant success.
Surface properties of titanium implants influence bone integration.
Current pretreatment methods can be complex or costly.

Purpose of the Study:

To evaluate the effect of sodium hypochlorite (NaOCl) pretreatment on titanium implant osseointegration.
To assess the impact of NaOCl on early bone-titanium fixation in a rat model.

Main Methods:

Titanium implants and disks were prepared and dual acid-etched.
Samples were pretreated with 5% NaOCl solution for 24 hours.
Morphological analysis, wettability tests, and biomechanical push-in tests were performed.

Main Results:

NaOCl treatment converted titanium surfaces from hydrophobic to superhydrophilic.
Surface hydrocarbon removal was observed after NaOCl treatment.
NaOCl-treated implants showed significantly greater bone-titanium integration strength (p<0.05).

Conclusions:

NaOCl pretreatment enhances the osseointegration capability of titanium.
This method offers a simple chemical approach for improving implant fixation.
NaOCl pretreatment shows potential as a chair-side method for enhancing implant success.