Eccrine Spiradenoma Arising from the Breast Skin

Area of Science:

• Dermatopathology
• Surgical Pathology

Background:

• Eccrine spiradenomas are uncommon benign neoplasms originating from eccrine sweat glands.
• These tumors typically affect young adults without a sex predilection.

Purpose of the Study:

• To report a case of eccrine spiradenoma occurring on the breast skin.
• To emphasize the importance of considering this diagnosis in superficial breast lesions.
• To describe the characteristic two-cell populations of eccrine spiradenoma.

Main Methods:

• Case presentation of a 39-year-old woman with a long-standing breast nodule.
• Histopathological examination of the lesion.
• Immunohistochemical analysis to identify cellular markers.

Main Results:

• The lesion was identified as an eccrine spiradenoma of the breast skin.
• The tumor exhibited two distinct cell populations: basaloid cells (P63+, calponin+) and larger inner cells (CK7+, CD117+).

Conclusions:

• Eccrine spiradenoma should be considered in the differential diagnosis of superficial, well-circumscribed breast skin or subcutaneous lesions.
• Recognizing the dual-cell population and their specific immunohistochemical profiles is crucial for accurate diagnosis.