Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serial Casting and Hinged Elbow Bracing in the Treatment of Fixed Flexion Deformity of the Elbow Following Obstetric Brachial Plexus Palsy.

Journal of pediatric orthopedics·2026
Same author

Re: Beaumont HOH, Wiberg A, Brown H, Quick TJ. Anatomic predisposition and neurologic vulnerability to brachial plexus birth injury: a contemporary narrative review. J Hand Surg Eur. 2026, 1-6.

The Journal of hand surgery, European volume·2026
Same author

Scientific evidence in non-stun slaughter.

The Veterinary record·2026
Same author

Flowing differently: exploratory characterization of menstrual effluent compared with peripheral blood.

F&S science·2026
Same author

Draft genome sequences of two <i>Pseudomonas</i> species from Lake St. Clair (Ontario, Canada) encode multiple heavy metal resistance determinants.

Microbiology resource announcements·2026
Same author

Selective neurectomy as surgical treatment for infrapatellar pain syndrome: A systematic review and meta-analysis.

Injury·2026

Related Experiment Video

Updated: Apr 6, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K

Extraskeletal Ewing's Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge.

Aadhar Sharma1, Kate Brown1, John Skinner2

  • 1Peripheral Nerve Injury Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, UK.

Case Reports in Surgery
|August 4, 2015
PubMed
Summary

This case study highlights an unusual sciatic nerve tumor in a 66-year-old, initially suspected to be benign. Diagnosis revealed extraosseous Ewing's sarcoma, emphasizing the need to consider rare peripheral nerve malignancies.

More Related Videos

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

632
Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
07:10

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

19.2K

Related Experiment Videos

Last Updated: Apr 6, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

13.0K
An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

632
Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
07:10

Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents

Published on: March 7, 2011

19.2K

Area of Science:

  • Oncology
  • Neurology
  • Pathology

Background:

  • Ewing's sarcoma is a pediatric bone tumor, rarely seen in adults.
  • Extraosseous Ewing's sarcoma originating from peripheral nerves is exceptionally rare.
  • Benign-appearing nerve sheath tumors can sometimes mask malignant pathologies.

Purpose of the Study:

  • To report an unusual case of extraosseous Ewing's sarcoma arising from the sciatic nerve in an elderly patient.
  • To discuss the diagnostic challenges and clinical presentation of this rare condition.
  • To emphasize the importance of considering rare peripheral nervous system tumors.

Main Methods:

  • Case presentation of a 66-year-old patient with a sciatic nerve mass.
  • Clinical assessment mimicking a benign nerve sheath tumor.
  • Surgical excision biopsy and histological confirmation of Ewing's sarcoma.
  • Multidisciplinary team discussion for treatment planning.

Main Results:

  • Histopathology confirmed Ewing's sarcoma, not a benign nerve sheath tumor.
  • The tumor presented with subtle malignant signs, including persistent pain.
  • Treatment involved radiotherapy and chemotherapy due to the risks of nerve resection.

Conclusions:

  • Extraosseous Ewing's sarcoma can present atypically, mimicking benign nerve sheath tumors.
  • Unremitting pain can be a subtle indicator of malignancy in peripheral nerve masses.
  • Clinicians must maintain a high index of suspicion for rare peripheral nervous system malignancies in adult patients.