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Related Experiment Video

Updated: Apr 6, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Emphysema mimicking interstitial lung disease: Two case reports.

Kasper S Juhl¹, Elisabeth Bendstrup¹, Finn Rasmussen²

¹Dpt. Respiratory Medicine and Allergology, Aarhus University Hospital, Aarhus, Denmark.

Respiratory Medicine Case Reports

|August 4, 2015

Summary

Honeycombing on CT scans can mimic pulmonary fibrosis. This study shows emphysema, inflammation, and embolism can create this appearance, highlighting diagnostic challenges in acute lung disease.

Keywords:

Emphysema HRCT Honeycombing Interstitial Mimicking Pulmonary embolism

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Published on: January 16, 2015

Area of Science:

Pulmonology
Radiology
Pathology

Background:

Honeycombing on High-Resolution Computed Tomography (HRCT) typically indicates severe, end-stage pulmonary fibrosis.
Differentiating various pulmonary conditions based on HRCT findings can be challenging, especially in acutely ill patients.

Observation:

Two cases are presented where a combination of emphysema, acute inflammation, and pulmonary embolism mimicked the HRCT appearance of honeycombing.
These findings occurred in patients with acute pulmonary infections.

Findings:

The study highlights that HRCT findings can be misleading in complex pulmonary cases.
Simultaneous acute and chronic pulmonary diseases present significant diagnostic hurdles.

Implications:

A multidisciplinary approach is crucial for diagnosing complicated pulmonary diseases.
Radiological interpretation requires careful consideration of clinical context in acute respiratory illness.