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Timolol-induced interstitial lung disease.

Hetain Patel1, Lina Vanessa Wilches1, Jorge Guerrero1

  • 1Division of Critical Care and Pulmonary Diseases, Florida Hospital Orlando, Orlando, FL, USA.

Respiratory Medicine Case Reports
|August 4, 2015
PubMed
Summary
This summary is machine-generated.

Timolol maleate eye drops can cause interstitial lung disease. This rare condition improved after stopping the medication and using corticosteroids.

Keywords:
Drug-inducedInterstitial lung diseaseTimolol maleate

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Area of Science:

  • Ophthalmology
  • Pulmonology
  • Pharmacology

Background:

  • Timolol maleate is a common non-selective beta-blocker used to treat open-angle glaucoma.
  • Glaucoma surgery is a common procedure, and post-operative complications require careful monitoring.

Observation:

  • A 76-year-old female developed cough, dyspnea, and hypoxia after initiating timolol maleate ophthalmic drops post-glaucoma surgery.
  • Initial symptoms were progressive, leading to significant respiratory distress.

Findings:

  • The patient was diagnosed with interstitial lung disease (ILD) causally linked to timolol maleate treatment.
  • Cessation of timolol maleate and initiation of corticosteroid therapy resulted in marked symptom improvement.
  • Radiological and functional assessments, after excluding other causes, confirmed timolol-induced ILD.

Implications:

  • This case highlights a rare but serious pulmonary side effect of topical timolol maleate.
  • Clinicians should consider drug-induced ILD in patients using timolol maleate who present with respiratory symptoms.
  • Early diagnosis and withdrawal of the offending agent are crucial for favorable outcomes in timolol-induced ILD.