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Updated: Apr 6, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
Published on: February 25, 2021
Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs.
Jafar Ezzati Nazhad Dolatabadi1, Hadi Valizadeh2, Hamed Hamishehkar3
1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran. ; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Solid lipid nanoparticles (SLNs) are versatile colloidal systems for advanced drug and gene delivery. This review covers SLN properties, production, characterization, and their application in targeted delivery systems.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmaceutical Sciences
Background:
- Nanomaterials are increasingly utilized as sophisticated drug and gene delivery systems.
- Solid lipid nanoparticles (SLNs) are prominent colloidal carriers for diverse therapeutic agents.
Purpose of the Study:
- To provide a comprehensive overview of solid lipid nanoparticles (SLNs) for drug and gene delivery.
- To review recent advancements in SLN-based delivery systems.
Main Methods:
- Review of existing literature on SLN structure, properties, and production.
- Analysis of recent studies on the application of SLNs in drug and gene delivery.
Main Results:
- SLNs can encapsulate both hydrophilic and lipophilic drugs, as well as macromolecules like proteins and nucleic acids.
- SLNs show potential for controlled and site-specific drug and gene delivery.
Conclusions:
- Solid lipid nanoparticles represent a promising platform for developing advanced drug and gene delivery nanosystems.
- Further research into SLN production and characterization can optimize their therapeutic applications.
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