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Updated: Apr 6, 2026

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
Host-guest Inclusion Complexes between Mitiglinide and the Naturally Occurring Cyclodextrins α, β, and γ: A
Khaldun Mohammad Al Azzam1, Ermafatiha Muhammad2
1Pharmacy Program, Batterjee Medical College for Science and Technology (BMC), 21442 Jeddah, Kingdom of Saudi Arabia.
Purpose:
The present study is aimed to study the host-guest inclusion complexation of the naturally occurring cyclodextrins (CDs), namely; (α-CD,β-CD, and γ-CD) with mitiglinide (MIT).
Methods:
Host-guest inclusion complexation was simulated using semi-empirical PM3 method.
Results:
The obtained results clearly indicate that the complexes formed are energetically favored in the presence of γ-CD (Ecomp = -17.884 kcal/mol) of the optimal configurations of (1:1) MIT/γ-CD inclusion complexes. Moreover, the results obtained reveal that the formation of more stable MIT/γ-CD complex compared to MIT/α-CD or MIT/β-CD complexes is primarily due to differences in intermolecular hydrogen bonding.
Conclusion:
The present theoretical results may be informative to scientists who are devoting themselves to developing effective methods for enhancing the drug solubility.
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