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Related Experiment Video

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Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
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Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation.

P Bhatti1, J Van Beek-King2, A Sharpe3

  • 1School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA ; Department of Rehabilitative Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

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|August 4, 2015
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Summary

We developed a silicone coating method to stiffen polymer electrode arrays for better intracochlear electrical stimulation. This technique enhances surgical handling and protects neural tissue, improving auditory brainstem response thresholds.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Thin-film polymer electrode arrays are used for intracochlear electrical stimulation.
  • Tailoring array flexibility is crucial for effective neural interfacing and surgical insertion.
  • Commercial arrays often require post-processing to meet specific application needs.

Purpose of the Study:

  • To present an effective method for modifying the flexibility of commercial thin-film polymer electrode arrays.
  • To enhance the performance and safety of electrode arrays for intracochlear electrical stimulation.
  • To improve surgical handling and neural tissue protection during implantation.

Main Methods:

  • A pneumatically driven dispensing system was used to apply a silicone adhesive coating.
  • The coating was applied to stiffen the underside of polyimide multisite arrays and protect neural tissue at the tip.
  • Microcomputed tomography imaging was used to measure array placement relative to the cochlea's modiolus.

Main Results:

  • An average silicone coating thickness of 232 ± 64 μm was achieved.
  • An average intracochlear stimulating current threshold of 170 ± 93 μA was reported for evoking auditory brainstem responses in felines.
  • Arrays were successfully inserted into the cochlea's basal turn, with microcomputed tomography confirming placement within 100–565 μm of the modiolus.

Conclusions:

  • The described postprocessing method effectively tailors the flexibility of commercial polymer electrode arrays.
  • The technique enhances array usability for intracochlear electrical stimulation, improving surgical handling and tissue protection.
  • This straightforward 24-hour postprocessing step offers a practical solution for optimizing electrode array performance.