Protein kinase-based neural signaling pathways for ginsenosides: a retrospective review

Ginsenosides are the main active components of ginseng, which have been reported to target brain tissues and produce multiple neuroprotective effects. Ginsenosides have been shown to improve learning ability and memory in normal aged animals, and in an animal model of memory impairment. However, its underlying pharmacological mechanisms are very complicated, especially with regard to its effects on the activation of protein kinases in neurons. Previous reports have shown that some protein kinases may be affected by ginsenosides, including protein kinase C, calcium/calmodulin-dependent protein kinase II, c-Jun-N terminal kinase, and protein tyrosine kinase. In this paper, protein kinases that may underlie the mechanisms of ginsenosides will be discussed.