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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Staphylococcal Skin Infections

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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[Cutaneous lupus erythematosus].

Tatjana Sandreva1, Anne Voss, Anette Bygum

  • 1Sdr. Boulevard 59, 2. th., 5000 Odense C. tatjana_sandreva@hotmail.com.

Ugeskrift for Laeger
|August 5, 2015
PubMed
Summary

Cutaneous lupus erythematosus (LE) is an autoimmune skin condition. Common forms include acute, subacute, and discoid LE, which can signal or accompany systemic lupus erythematosus (SLE).

Area of Science:

  • Immunodermatology
  • Autoimmune diseases

Background:

  • Cutaneous lupus erythematosus (LE) is an autoimmune condition affecting the skin.
  • Key clinical forms include acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE), and discoid LE (DLE).
  • Cutaneous LE manifestations are present in up to 85% of patients with systemic LE (SLE) and can be an early indicator of SLE.

Purpose of the Study:

  • To provide an overview of cutaneous lupus erythematosus.
  • To discuss the relationship between cutaneous and systemic lupus erythematosus.
  • To outline the etiology and management of cutaneous LE.

Main Methods:

  • Literature review of cutaneous lupus erythematosus.
  • Analysis of clinical presentations and associations with systemic lupus erythematosus.

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  • Summary of etiological factors and treatment modalities.

    • Main Results:

    • Cutaneous LE presents in several forms, with ACLE, SCLE, and DLE being most common.
    • ACLE can be the initial manifestation of SLE, while DLE and SCLE have a lower association with SLE development.
    • Etiology is multifactorial, including drug induction (e.g., proton pump inhibitors for SCLE), UV light, and smoking.

    Conclusions:

    • Cutaneous lupus erythematosus encompasses diverse clinical forms with varying associations to systemic lupus erythematosus.
    • Understanding the triggers and manifestations of cutaneous LE is crucial for patient management.
    • Treatment involves preventive measures, topical corticosteroids, and systemic hydroxychloroquine.