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Long non-coding RNA HOTAIR: A novel oncogene (Review)
1Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, P.R. China.
Molecular Medicine Reports
|August 5, 2015
Summary
Long non-coding RNAs (lncRNAs), like HOTAIR, are crucial in cancer development and progression. Aberrant HOTAIR expression correlates with poor prognosis in various cancers, highlighting its role in tumor growth and metastasis.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are key epigenetic regulators.
- Aberrant lncRNA expression is linked to human cancers.
- HOX transcript antisense intergenic RNA (HOTAIR) is frequently upregulated in various cancers.
Purpose of the Study:
- To review the current knowledge on HOTAIR's role in cancer.
- To highlight HOTAIR's involvement in tumor initiation, development, and metastasis.
Main Methods:
- Literature review of studies on HOTAIR and cancer.
- Analysis of HOTAIR expression levels and patient prognosis.
- Examination of HOTAIR's functional roles in cancer biology.
Main Results:
- HOTAIR is overexpressed in multiple cancer types, including breast, esophageal, lung, and gastric cancers.
- High HOTAIR expression is associated with significantly poorer patient prognosis.
- HOTAIR influences critical cancer processes: apoptosis, growth, metastasis, angiogenesis, DNA repair, and metabolism.
Conclusions:
- HOTAIR is a significant factor in human cancer development and progression.
- HOTAIR's multifaceted roles make it a potential biomarker and therapeutic target in oncology.
