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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

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Gene expression in prolactinomas: a systematic review.

Justin Seltzer¹, Thomas C Scotton², Keiko Kang³

¹Department of Neurosurgery, Keck School of Medicine of USC, 1200 North State St., Los Angeles, CA, 90033, USA. jseltzer@usc.edu.

|August 5, 2015

Summary

This study identifies key genes in prolactinomas, the most common pituitary tumors. These molecular markers offer potential for new diagnostic tools and targeted therapies for treatment-resistant cases.

Keywords:

Gene expression Lactotroph Pituitary adenoma Prolactin Prolactinoma Protein expression

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Published on: April 2, 2018

Area of Science:

Endocrinology
Molecular Biology
Oncology

Background:

Prolactinomas are common functional pituitary adenomas.
Current classifications lack molecular markers.
Treatment options are limited for refractory cases.

Purpose of the Study:

To review gene and protein expression in prolactinomas.
To identify molecular variations linked to tumor development and function.
To highlight potential therapeutic and diagnostic targets.

Main Methods:

Systematic literature review following PRISMA guidelines.
PubMed search for gene and protein expression studies (1990-2014).
Analysis of identified upregulated and downregulated genes.

Main Results:

51 studies analyzed, identifying 54 upregulated and 95 downregulated genes.
Key upregulated genes: HMGA2, HST, SNAP25.
Key downregulated genes: UGT2B7, Let7, miR-493.

Conclusions:

Numerous significant genes identified in prolactinomas.
These genes hold potential for biomarker development.
Further research can advance precision medicine for prolactinomas.