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Related Concept Videos

Proteomics01:33

Proteomics

10.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
394

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Proteomics in obesity research.

Sílvia Barceló-Batllori1, Ramon Gomis2,3

  • 1Proteomics Unit, Aragon Health Sciences Institute (ICS), Zaragoza, Spain. sbarcelo.iacs@aragon.es.

Proteomics. Clinical Applications
|August 5, 2015
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Summary

Obesity is a complex global epidemic. Proteomics helps unravel its molecular causes and identify potential therapies by studying adipose tissue and cell signaling.

Keywords:
AdipocyteAdipose tissueObesityProteomicsSecretome

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Background:

  • Obesity is a major global epidemic with increased morbidity and mortality.
  • It is a complex disease involving energy imbalance and affecting quality of life.
  • Obesity increases the risk of diabetes mellitus, insulin resistance, and cardiovascular disease.

Purpose of the Study:

  • To review the contributions of proteomics to understanding obesity.
  • To explore how proteomics aids in identifying molecular mechanisms and potential therapies for obesity.

Main Methods:

  • Proteomic studies focusing on adipose tissue protein profiling in obesity models.
  • Analysis of adipocyte differentiation and secretome characterization.
  • Proteomics for identifying therapeutic targets in obesity.

Main Results:

  • Proteomics offers insights into the pathogenesis of obesity.
  • Studies have characterized adipose tissue proteins and adipocyte secretomes.
  • Proteomic approaches are being used to identify potential obesity therapies.

Conclusions:

  • Proteomics is a valuable tool for elucidating obesity's molecular underpinnings.
  • Understanding these mechanisms can lead to the development of novel therapeutic strategies.
  • Further proteomic research is crucial for combating the obesity epidemic.