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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Updated: Apr 6, 2026

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
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Tapping Stem Cells to Target AMD: Challenges and Prospects.

Caroline Brandl1,2, Felix Grassmann3, Julia Riolfi4

  • 1Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. Caroline.Brandl@klinik.uni-regensburg.de.

Journal of Clinical Medicine
|August 5, 2015
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cells (hPSCs) offer a "patient in a dish" model for complex diseases like age-related macular degeneration (AMD). This review explores their use in AMD research and potential stem cell therapies.

Keywords:
RNA-sequencingage-related macular degeneration (AMD)cell-based transplantation therapydisease modellingdrug screeninginduced pluripotent stem cells (iPSCs)retinal pigment epithelium (RPE)stem cells

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Area of Science:

  • Biomedicine
  • Regenerative Medicine
  • Ophthalmology

Background:

  • Human pluripotent stem cells (hPSCs) are valuable for patient-derived cell culture models.
  • Inherited retinal diseases, such as age-related macular degeneration (AMD), present unique challenges due to individual genetic and metabolic factors.
  • Current animal models inadequately capture the complexity of human retinal diseases.

Purpose of the Study:

  • To review the current status and future prospects of using hPSCs, particularly induced pluripotent stem cells (iPSCs), in AMD research.
  • To outline concepts for AMD disease modeling using hPSCs.
  • To summarize clinical trials for stem cell-based therapy in late-stage AMD.

Main Methods:

  • Review of current literature on hPSC applications in AMD research.
  • Analysis of disease modeling strategies using iPSCs.
  • Summary of ongoing and projected clinical trials for stem cell therapy in AMD.

Main Results:

  • hPSCs, especially iPSCs, show significant promise for creating "patient-in-a-dish" models of AMD.
  • These models can help elucidate the complex genetic and individual factors contributing to AMD.
  • Stem cell-based therapies are being explored for late-stage AMD with ongoing clinical trials.

Conclusions:

  • hPSCs represent a powerful tool for advancing basic and clinical research in age-related macular degeneration.
  • The development of patient-derived iPSC models facilitates a deeper understanding of AMD pathogenesis.
  • Stem cell therapies hold potential for treating advanced AMD, with active clinical investigations underway.