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Updated: Apr 6, 2026

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
Published on: October 25, 2024
Imaging of atherosclerosis
Richard A P Takx1,2, Sasan Partovi3, Brian B Ghoshhajra4
1Cardiac MR PET CT Program, Harvard Medical School, Massachusetts General Hospital, 165 Cambridge Street, Suite 400, Boston, MA, 02114-2750, USA.
Insights
Atherosclerosis, a key cause of cardiovascular disease (CVD), can be assessed using various imaging techniques. These methods aid in risk stratification and treatment planning for better patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Medical Imaging
- Inflammatory Diseases
Background:
- Cardiovascular disease (CVD) is a leading global health issue.
- Atherosclerosis, a chronic inflammatory disease causing plaque buildup, is the primary driver of CVD.
- Effective imaging is crucial for managing atherosclerosis and guiding therapeutic interventions.
Purpose of the Study:
- To provide a comprehensive overview of coronary and non-coronary atherosclerosis.
- To summarize current understanding and applications of various imaging modalities for atherosclerosis assessment.
- To highlight the potential of integrated imaging techniques for improved clinical practice.
Main Methods:
- Review of established imaging modalities: ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and interventional angiography.
- Discussion of advanced hybrid imaging techniques, such as PET/MRI, for simultaneous anatomical and metabolic assessment.
- Analysis of the role of these imaging techniques in evaluating atherosclerotic burden and predicting cardiovascular events.
Main Results:
- Multiple imaging techniques are available for assessing atherosclerotic burden and predicting future cardiovascular events.
- Hybrid imaging like PET/MRI offers simultaneous evaluation of anatomical and metabolic tissue characteristics.
- Current imaging modalities provide valuable data for risk stratification and therapeutic planning.
Conclusions:
- Imaging plays a vital role in assessing atherosclerosis and guiding therapeutic strategies.
- Integration of diverse imaging techniques can enhance risk stratification and treatment monitoring.
- Advanced imaging approaches promise superior management of cardiovascular disease through better understanding of atherosclerosis.
Abstract:
Cardiovascular disease (CVD) is a major health concern worldwide and atherosclerosis is the main cause of CVD. Atherosclerosis is a systemic and chronic inflammatory disease, which is characterized by plaque formation and can affect different vascular beds. Imaging of atherosclerosis could guide therapeutic interventions. Ultrasound, computed tomography, magnetic resonance imaging (MRI), positron emission tomography (PET) and interventional angiography are the main imaging modalities available for the assessment of atherosclerotic burden and for potential prediction of future events. In addition, the introduction of new hybrid imaging techniques like PET/MRI allow for the simultaneous evaluation of anatomical and metabolic characteristics tissues. This article provides an overview of coronary and non-coronary atherosclerosis and summarizes the current understanding of different available imaging techniques. The integration of these techniques in clinical practice may allow for superior risk stratification and therapeutic planning as well as monitoring of interventional and medication based treatment strategies.
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