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Related Concept Videos

Design Example01:23

Design Example

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The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...
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Determination of Expected Frequency01:08

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Suppose one wants to test independence between the two variables of a contingency table. The values in the table constitute the observed frequencies of the dataset. But how does one determine the expected frequency of the dataset? One of the important assumptions is that the two variables are independent, which means the variables do not influence each other. For independent variables, the statistical probability of any event involving both variables is calculated by multiplying the individual...
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Atomic Nuclei: Larmor Precession Frequency01:11

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The earth's gravitational field produces a 'twisting force' perpendicular to the angular momentum of a spinning mass (such as a spinning top) that causes the mass to 'wobble' around the gravitational field axis in a phenomenon called precession. Similarly, the magnetic moment (μ) of a spinning nucleus precesses due to an external magnetic field directed along the z-axis. The precession of the magnetic moment vector about the magnetic field is called Larmor precession,...
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IR Frequency Region: Fingerprint Region01:03

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IR spectra are divided into two main regions: the diagnostic region and the fingerprint region. The diagnostic region of the spectrum lies above 1500 cm−1. The absorptions resulting from single-bond vibrations of the N–H, C–H, and O–H stretch at higher wavenumbers and appear on the left side of the spectrum. The stretching absorptions of the C≡C and C≡N occur between 2100–2300 cm−1. In contrast, those arising from stretching absorptions of the...
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NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

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A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
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Cut-off Frequency of BJT01:17

Cut-off Frequency of BJT

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Cut-off frequencies in Bipolar Junction Transistors (BJTs) mark the transition between the signal's pass band and stop band, influencing their performance in amplifying or attenuating frequencies. These frequencies are crucial for designing BJTs to meet specific operational requirements in electronic circuits.
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Related Experiment Video

Updated: Apr 6, 2026

A Simple Approach to Perform TEER Measurements Using a Self-Made Volt-Amperemeter with Programmable Output Frequency
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The APP A673T frequency differs between Nordic countries.

Jonas Mengel-From1, Bernard Jeune2, Tienari Pentti3

  • 1The Danish Aging Research Center and The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography Unit, Department of Public Health, University of Southern Denmark, Odense, Denmark; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.

Neurobiology of Aging
|August 5, 2015
PubMed
Summary
This summary is machine-generated.

The APP gene

Keywords:
AgingAlzheimersAmyloid betaCognitionDementia

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Area of Science:

  • Genetics
  • Neuroscience
  • Population Studies

Background:

  • A specific gene variant, APP A673T, is linked to protection against late-onset Alzheimer's Disease and longevity in Nordic populations.
  • Its rarity in non-Nordic populations has limited replication studies.

Purpose of the Study:

  • To investigate the frequency of the APP A673T variant in the Danish population.
  • To explore potential associations with longevity and cognitive function in Danes.

Main Methods:

  • Genotyping of the APP A673T variant in a cohort of Danish twins and oldest-old singletons.
  • Statistical analysis to determine variant frequency and compare with other Nordic countries.

Main Results:

  • The APP A673T variant was found in only 0.014% of the 3487 unrelated Danes studied.
  • This frequency is significantly lower than the average of 0.43% observed in other Nordic countries.

Conclusions:

  • The APP A673T variant is exceptionally rare in Danes compared to other Nordic populations.
  • This low frequency prevents the assessment of its association with longevity or cognitive function in this population.