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Polypoidal Choroidal Vasculopathy in Asians.

Chee Wai Wong1,2, Tien Y Wong3,4, Chui Ming Gemmy Cheung5,6

  • 1Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Avenue, 168751 Singapore, Singapore. wongcheewai81@gmail.com.

Journal of Clinical Medicine
|August 5, 2015
PubMed
Summary
This summary is machine-generated.

Polypoidal choroidal vasculopathy (PCV) is common in Asians with age-related macular degeneration (AMD), differing from Western AMD. Optimal PCV treatment requires further study, as current therapies like photodynamic therapy (PDT) show unsatisfactory long-term results.

Keywords:
Asiansanti vascular endothelial growth factorepidemiologygeneticsphotodynamic therapypolypoidal choroidal vasculopathyrisk factors

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Area of Science:

  • Ophthalmology
  • Genetics
  • Biomarkers

Background:

  • Age-related macular degeneration (AMD) exhibits distinct epidemiological and clinical characteristics in Asian populations compared to Westerners.
  • Polypoidal choroidal vasculopathy (PCV) is the predominant exudative AMD subtype in Asians, unlike choroidal neovascularization secondary to AMD (CNV-AMD) prevalent in the West.

Purpose of the Study:

  • To explore the epidemiological, pathogenic, and clinical differences between PCV and CNV-AMD.
  • To review current understanding of risk factors, biomarkers, genetic determinants, and treatment strategies for PCV and CNV-AMD.

Main Methods:

  • Literature review and analysis of epidemiological data, focusing on PCV and CNV-AMD.
  • Examination of serum biomarkers (CRP, homocysteine, MMPs) and genetic sequencing data.
  • Comparison of treatment outcomes for PCV (photodynamic therapy - PDT) and CNV-AMD (anti-vascular endothelial growth factor - VEGF therapy).

Main Results:

  • PCV and CNV-AMD share some pathogenic mechanisms but also have differential underlying causes, suggested by risk factor profiles.
  • Biomarkers indicate roles for inflammation, atherosclerosis, and extracellular matrix metabolism in pathogenesis.
  • Genetic studies reveal distinct genetic determinants for PCV and CNV-AMD.

Conclusions:

  • PCV is a significant subtype of exudative AMD in Asians, necessitating further research into its optimal management.
  • Current treatments for PCV, primarily PDT, yield unsatisfactory long-term visual prognosis.
  • Investigating novel therapeutic approaches, including different anti-VEGF agents and reduced fluence PDT, is crucial for improving PCV outcomes.