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Updated: Apr 6, 2026

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
Regenerative cellular therapies for neurologic diseases
Michael Levy1, Nicholas Boulis2, Mahendra Rao3
1Department of Neurology, Johns Hopkins University, Baltimore, MD, United States.
Stem cell transplantation offers hope for neurological conditions, with numerous trials underway for diseases like Parkinson's and multiple sclerosis. While no stem cell therapy is currently approved, this review details active trials for various central nervous system disorders.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Cell Biology
Background:
- Neurologic patients with permanent central nervous system damage have long awaited regenerative therapies.
- Hundreds of global stem cell trials are investigating the potential of stem cell transplantation for neurological conditions.
- Despite no approved stem cell therapies, patient interest and clinical inquiries are rising.
Purpose of the Study:
- To review the current status of regenerative stem cell transplantation.
- To summarize active clinical trials for seven specific neurological conditions.
Main Methods:
- Literature review of ongoing stem cell transplantation trials.
- Categorization of trials based on neurological condition.
Main Results:
- Active stem cell transplantation trials exist for demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's disease, macular degeneration, and peripheral nerve diseases.
- No stem cell therapy is currently approved for human use across any disease indication.
Conclusions:
- Stem cell transplantation is under active investigation for a range of severe neurological disorders.
- This review provides an overview of the current landscape of stem cell regenerative medicine for the central nervous system.
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