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Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
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Oritavancin Pharmacokinetics and Bone Penetration in Rabbits
Dario Lehoux1, Valerie Ostiguy2, Cordelia Cadieux2
1The Medicines Company, St. Laurent, Quebec, Canada dario.lehoux@themedco.com.
Antimicrobial Agents and Chemotherapy
|August 5, 2015
Summary
Oritavancin rapidly distributes to bone tissue and maintains stable concentrations for up to 168 hours in rabbits. These findings support further investigation of oritavancin for treating bone infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Bone Biology
Background:
- Oritavancin is a lipoglycopeptide antibiotic.
- Bone infections require effective antimicrobial penetration into osseous tissues.
Purpose of the Study:
- To evaluate the pharmacokinetics and bone tissue concentrations of oritavancin.
- To determine the duration of oritavancin presence in bone following intravenous administration.
Main Methods:
- A single intravenous dose of oritavancin was administered to rabbits.
- Pharmacokinetic parameters and bone concentrations were measured over 168 hours.
Main Results:
- Oritavancin exhibited rapid distribution into rabbit bone tissues.
- Sustained concentrations of oritavancin in bone were observed up to 168 hours post-dose.
Conclusions:
- Oritavancin demonstrates favorable pharmacokinetic properties in bone tissue.
- Further research into oritavancin for bone infection treatment is justified.
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